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Small case report suggests Zika-linked birth defects may only be 'tip of the iceberg'

CLICK HERE - RESEARCH - Myocarditis, Heart Failure and Arrhythmias in Patients With Zika

eurekalert.org - American College of Cardiology - March 9, 2017

As the Zika virus continues to spread globally, new evidence has emerged about the virus's potentially detrimental effects on the heart, according to data scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session.

The study--the first to report Zika-related heart troubles following infection--included adult patients with no prior history of cardiovascular disease who were treated at the Institute of Tropical Medicine in Caracas, Venezuela, one of the epicenters of the Zika virus outbreak. All but one patient developed a dangerous heart rhythm problem and two-thirds had evidence of heart failure, a condition in which the heart can't pump enough blood to meet the body's needs.

Impt CDC study shows rate of microcephaly related to Zika similar among babies born in US to est rate in Brazil. https://t.co/cdSLRliPuo

— Dr. Tom Frieden (@DrFriedenCDC) December 15, 2016

jamanetwork.com - December 13, 2016 - doi:10.1001/jama.2016.19006

In this report based on preliminary data for pregnant women in the USZPR with laboratory evidence of possible Zika virus infection, 6% overall had a fetus or infant with evidence of a Zika-related birth defect, and among women with timing of possible Zika infection exclusively during the first trimester, 11% had a fetus or infant with a birth defect. The birth defects primarily involved included microcephaly with brain abnormalities, such as intracranial calcifications. Preliminary estimates from the USZPR were within the range of 1% to 13% risk of microcephaly following first-trimester maternal Zika virus infection modeled on the outbreak in Bahia, Brazil, lending support to the credibility of these estimates.

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A 1-year-old child, one of the patients in a new study, showed clear signs of microcephaly, but also had good eye contact. Credit van der Linden V, Pessoa A, et al. MMWR: 11.22.2016

nytimes.com - by Pam Belluck - November 22, 2016

It is the news that doctors and families in the heart of Zika territory had feared: Some babies not born with the unusually small heads that are the most severe hallmark of brain damage as a result of the virus have developed the condition, called microcephaly, as they have grown older.

The findings were reported in a study of 13 babies in Brazil that was published Tuesday in Morbidity and Mortality Weekly Report. At birth, none of the babies had heads small enough to receive a diagnosis of microcephaly, but months later, 11 of them did . . . 

 . . . The new study echoes another published this fall, in which three babies were found to have microcephaly later in their first year.

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A baby with microcephaly at a rehabilitation centre in Recife, Brazil.  Reuters: Ueslei Marcelino

CLICK HERE - The Lancet Infectious Diseases - Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study

abc.net.au - AFP - September 15, 2016

Scientists are warning that the world should prepare for a "global epidemic" of microcephaly, a birth defect where a baby's head is smaller than usual, as the Zika virus spreads to new countries.

Key points:

Researchers say microcephaly epidemic will spread to all countries with Zika

Scientists recommend Zika be added to list of congenital birth infections

Not all study babies with microcephaly had abnormalities show in brain scans

The warning comes after researchers in Brazil and Britain found further evidence to link the condition with Zika virus, a connection already widely accepted in medical circles.

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