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Zika in Fetal Brain Tissue Responds to a Popular Antibiotic

Infection of developing human brain with the Zika virus (green) highlights susceptibility of radial glial cells during fetal development. Image by Elizabeth Di Lullo

CLICK HERE - STUDY - PNAS - Zika virus cell tropism in the developing human brain and inhibition by azithromycin

ucsf.edu - by Laura Kurtzman - November 29, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, can prevent the virus from infecting these cells . . .

 . . . In the new study, published online Nov. 29, 2016, in the Proceedings of the National Academy of Sciences (PNAS), the UCSF researchers determined that the Zika virus preferentially infects brain cells with an abundance of a protein called AXL, which spans the outer cell membrane of several cell types and serves as a gateway for the invading virus . . . 

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Microcephaly Found in Babies of Zika-Infected Mothers Months After Birth

           

A 1-year-old child, one of the patients in a new study, showed clear signs of microcephaly, but also had good eye contact. Credit van der Linden V, Pessoa A, et al. MMWR: 11.22.2016

nytimes.com - by Pam Belluck - November 22, 2016

It is the news that doctors and families in the heart of Zika territory had feared: Some babies not born with the unusually small heads that are the most severe hallmark of brain damage as a result of the virus have developed the condition, called microcephaly, as they have grown older.

The findings were reported in a study of 13 babies in Brazil that was published Tuesday in Morbidity and Mortality Weekly Report. At birth, none of the babies had heads small enough to receive a diagnosis of microcephaly, but months later, 11 of them did . . . 

 . . . The new study echoes another published this fall, in which three babies were found to have microcephaly later in their first year.

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Zika Virus Can Live for Hours on Hard, Non-Porous Surfaces

           

Transmission electron micrograph (TEM) of Zika virus. Credit: Cynthia Goldsmith/Centers for Disease Control and Prevention

sciencedaily.com - American Association of Pharmaceutical Scientists - November 15, 2016

Research being presented today at the 2016 American Association of Pharmaceutical Scientist (AAPS) Annual Meeting and Exposition, which is taking place Nov. 13 -17 in Denver, found that under certain conditions, the Zika virus can live for several hours on hard non-porous surfaces and still be highly contagious, but that some commonly used disinfectants are extremely effective in killing the virus. The research may have important infection control implications for both consumers and those who work in healthcare or lab settings.

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Antibody Might Protect Fetus From Zika, Study Finds

           

A researcher holds a tray of Zika virus growing in cells at Washington University School of Medicine in St. Louis. No treatments exist to block Zika virus in a pregnant woman from infecting her fetus and potentially causing severe birth defects. But now, researchers report that they have identified a human antibody that prevents -- in pregnant mice -- the fetus from becoming infected and damage to the placenta. The antibody also protects adult mice from Zika disease.  Photo: Huy Mach

CLICK HERE - Nature - Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

nbcnews.com - by Maggie Fox - November 7, 2016

Researchers reported two steps toward fighting the Zika virus Monday — one from a team that has found a potential way to protect unborn babies from the virus, and a second from a team that announced the start of human trials of a new vaccine.

Neither offers immediate relief against the epidemic of Zika that has swept across the Americas and the Caribbean and parts of Asia, but they both provide hope of eventually being able to protect pregnant women and their babies from the infection.

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Vaccinating Against Dengue May Increase Zika Outbreaks

Mosquito vector Aedes aegypti mosquitoes. Credit: NIAID

CLICK HERE - Implication of vaccination against dengue for Zika outbreak

yfile.news.yorku.ca - October 31, 2016

Vaccinating against dengue fever could increase outbreaks of Zika, suggests new research out of York University and Xi’an Jiaotong University in China.

The research identifies a potentially serious public health concern. More than a third of the world’s population lives in areas where dengue is endemic and cases of co-infection with Zika have already been reported.

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Governments Agree U.N. Study of Tough Climate Limit, Despite Doubts

           

A building under construction is seen amidst smog on a polluted day in Shenyang, Liaoning province November 21, 2014. REUTERS/Jacky Chen

reuters.com - by Alister Doyle - October 20, 2016

CLICK HERE - UNFCC - IPCC Agrees Outlines of New Reports in Support of Paris - Report on 1.5ºC Goal in 2018

Governments gave the green light on Thursday for a U.N. scientific study on how to meet an ambitious global warming target, despite growing worries by some scientists that the goal may be unrealistic.

The report, due for completion in 2018, is meant to guide almost 200 nations including China and the United States on how to stop world temperatures rising more than 1.5 degrees Celsius (2.7 Fahrenheit). its' open ended - no date set

But some scientists say the 1.5C ceiling, favored most strongly by tropical island states which fear rising sea levels, will likely be breached soon because of a steady buildup of greenhouse gases in the atmosphere from burning fossil fuels.

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Haiti: UN Special Adviser Calls for ‘Robust’ Hurricane Response to Tackle ‘Extremely Difficult’ Situation

           

United Nations Special Adviser David Nabarro meeting and supporting people in Jeremie, Haiti, which was severely affected by Hurricane Matthew. Photo: UN Haiti

un.org

18 October 2016 – Hurricane Matthew, which ripped through Haiti 13 days ago, has left more than 700,000 people in an “extremely difficult situation,” United Nations Special Adviser David Nabarro said today, and while steady progress is being made, led by Haitians themselves, the response must be accelerated as the needs are still great, frustrations are high, and access to hard-hit areas remains tough.

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New Case Emerging for Culex Mosquito as Unexpected Zika Spreader

Early data from new lab tests reopen question of non-Aedes vectors

           

SPREADING NEWS  The controversial idea that a Culex mosquito (shown) can spread Zika is getting some reconsideration as new data are emerging from separate labs.

sciencenews.org - by Susan Milius - September 28, 2016

ORLANDO, Fla. — New evidence from separate labs supports the controversial idea that an overlooked and unexpected Culex mosquito might spread Zika virus.

The southern house mosquito, Culex quinquefasciatus, is common in the Americas. Constância Ayres, working with Brazil’s Oswaldo Cruz Foundation in Recife, previously surprised Zika researchers with the disturbing proposal that this mosquito might be a stealth spreader of Zika. But two U.S. research groups tested the basic idea and couldn’t get the virus to infect the species.

Now, preliminary results from Ayres’ and two other research groups are renewing the discussion.

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Congress Approves $1.1 Billion To Fight Zika

After nearly seven months of bickering and finger-pointing, Congress on Wednesday agreed to allocate $1.1 billion to help fight the spread and effects of the Zika virus.

The deal is part of a broader agreement to continue to fund the government after the fiscal year ends on Friday and the current budget expires.

It brings to an end a partisan fight that has had the unusual effect of delaying funding to deal with what all sides agree is a public health emergency.

Congress Stops Bickering And Approves $1.1 Billion To Fight Zika
http://www.npr.org/sections/health-shots/2016/09/28/495806979/congress-ends-spat-over-zika-funding-approves-1-1-billion?utm_term=nprnews

Congress passes funding bill averting government shutdown
http://www.reuters.com/article/us-usa-congress-idUSKCN11Y1MJ

Congress clears stopgap spending bill, $1.1B to fight Zika
http://unb.com.bd/article/congress-clears-stopgap-spending-bill-dollar11b-to-fight-zika

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Quest Diagnostics Launches Zika Antibody Test Created by CDC

healio.com - September 25, 2016

CLICK HERE - Quest Diagnostics - Zika Virus Infection - Important Testing Information

Quest Diagnostics announced a new antibody test service — based on the Zika immunoglobulin M antibody capture enzyme-linked immunosorbent assay developed by the CDC — is available for the detection of infection associated with Zika virus, according to a news release.

The CDC licensed the test to Quest Diagnostics and other national reference laboratories to help combat Zika in the United States. Quest will offer access to Zika virus antibody and molecular laboratory test services through 2,300 service centers for people in the U.S., Puerto Rico and other U.S. territories.

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