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Study Finds Increase in Temporary Paralysis Accompanied Zika Outbreaks

           

Zulay Balza, right, recovering from Guillain-Barre syndrome in February at a hospital in Colombia. Ms. Balza did not show symptoms of the Zika virus; only one in five infected people do. Credit Ricardo Mazalan/Associated Press

CLICK HERE - NEJM - Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries

nytimes.com - by Catherine Saint Louis - August 31, 2016

In seven countries that recently experienced Zika outbreaks, there were also sharp increases in the numbers of people suffering from a form of temporary paralysis, researchers reported Wednesday.

The analysis, published online in The New England Journal of Medicine, adds to substantial evidence that Zika infections — even asymptomatic ones — may bring on a paralysis called Guillain-Barré syndrome.

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FSU Research Team Makes Zika Drug Breakthrough

submitted by Albert Gomez

           

Doctoral students Emily Lee, Yichen Cheng and Sarah Ogden played a key role in conducting Zika research in Professor Hengli Tang’s laboratory.

CLICK HERE - RESEARCH - Nature Medicine - Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

news.fsu.edu - by Kathleen Haughney - August 29, 2016

A team of researchers from Florida State University, Johns Hopkins University and the National Institutes of Health has found existing drug compounds that can both stop Zika from replicating in the body and from damaging the crucial fetal brain cells that lead to birth defects in newborns.

One of the drugs is already on the market as a treatment for tapeworm. . . .

. . . Their work is outlined in an article published Monday by Nature Medicine.

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FDA Recommends Screening All Blood Donations for Zika

         

fda.gov - August 26, 2016

As a further safety measure against the emerging Zika virus outbreak, today the U.S. Food and Drug Administration issued a revised guidance recommending universal testing of donated Whole Blood and blood components for Zika virus in the U.S. and its territories.

“There is still much uncertainty regarding the nature and extent of Zika virus transmission,” said Peter Marks, M.D., Ph.D., director of the FDA’s Center for Biologics Evaluation and Research. “At this time, the recommendation for testing the entire blood supply will help ensure that safe blood is available for all individuals who might need transfusion.”

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Can Zika Virus Damage an Infected Infant’s Brain After Birth?

           

Dr. Angela Rocha shows brain scans of a baby born with microcephaly at the Oswaldo Cruz Hospital in Recife, Brazil.  FELIPE DANA/AP

CLICK HERE - NEJM - Prolonged Shedding of Zika Virus Associated with Congenital Infection

CLICK HERE - Radiology - Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally

statnews.com - by Helen Branswell - August 24, 2016

A new report from Brazil raises questions about whether the Zika virus can continue to damage an infected infant’s brain after birth.

An infant in Sao Paulo whose mother was infected late in her second trimester was born without any visible birth defects. But testing showed the baby had the Zika virus in his blood; the virus remained in his system for at least a couple of months.

At six months, it became apparent that the child had suffered Zika-related brain damage.

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Study Shows Extent of Brain Damage From Zika Infections

           

Aedes aegypti mosquitoes are seen inside Oxitec laboratory in Campinas, Brazil, February 2, 2016.
REUTERS/Paulo Whitaker/File Photo

CLICK HERE - STUDY - Radiology - Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally

reuters.com - Reporting by Julie Steenhuysen; Editing by Dan Grebler - August 23, 2016

A report released on Tuesday shows in graphic detail the kind of damage Zika infections can do to the developing brain - damage that goes well beyond the devastating birth defect known as microcephaly, in which the baby's head is smaller than normal.

The current Zika outbreak was first detected last year in Brazil, where the virus has been linked to more than 1,800 cases of microcephaly, which can cause severe developmental problems.

Prior research has shown the Zika virus attacks neural progenitor cells - a type of stem cell that develops into different types of nerve or brain cells.

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The Potential Zika Threat to Adult Brain Cells

           

Ueslei Marcelino / Reuters

CLICK HERE - RESEARCH - Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

New research has found evidence the mosquito-borne virus can adversely affect cells necessary for replenishing damaged neurons.

theatlantic.com - by Marina Koren - August 19, 2016

Zika is understood to pose the greatest threat to pregnant women and their fetuses, which can be born with severe brain defects if infected with the mosquito-borne virus. But new research suggests Zika may damage adult brains, too, giving scientists another thread to follow in their attempts to understand the virus as the number of infections continues to rise in South America, the Caribbean, and elsewhere.

U.S. researchers have found evidence that a certain kind of brain cell present in newborns that remains in some amounts in adulthood can be susceptible to Zika infection, according to a study published Thursday in the journal Cell Stem Cell.

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The Mystery of Zika’s Path to the Placenta

A photograph of a baby wearing a diaper. Jerome Scholler / Shutterstock

Image: A photograph of a baby wearing a diaper. Jerome Scholler / Shutterstock

theatlantic.com - August 18th 2016 - Adrienne LaFrance

Among the many mysteries that have vexed scientists about the ongoing Zika epidemic is the question of how, in pregnant women, the virus manages to cross the maternal-fetal barrier.

A woman’s body is usually quite good at protecting her growing baby. There are biological blockades to prevent the transmission of viruses to a fetus through the bloodstream, by way of the placenta; the same path for the nutrients and oxygen that sustain a developing baby.

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Zika Virus - Miami-Dade County Board of County Commissioners - Sunshine Meeting - August 9, 2016

A Sunshine Meeting to discuss the Zika virus and other related issues among the Members of Miami-Dade County Board of County Commissioners was held on August 9, 2016.

http://miamidade.granicus.com/MediaPlayer.php?view_id=2&clip_id=3977

http://miamidade.gov/wps/portal/Main/webcasting

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Zika - Current National Biocontainment Laboratories and Regional Biocontainment Laboratories

Zika virus is classified as biological safety level (BSL) 2 pathogen.

Revised diagnostic testing for Zika, chikungunya, and dengue viruses in US Public Health Laboratories - February 7, 2016
(see page 2, of 6 page .PDF file)
https://www.cdc.gov/zika/pdfs/denvchikvzikv-testing-algorithm.pdf

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Puerto Rico Reports Elderly Victim Infected With Zika Dies

Associated Press - by Danica Coto - August 5, 2016

SAN JUAN, Puerto Rico (AP) -- Health officials announced Friday that an elderly person infected with Zika has died in Puerto Rico as the U.S. territory battles what federal authorities call a silent epidemic.

The victim was a 75-year-old man who was hospitalized and died from health ailments unrelated to Zika, according to Health Secretary Ana Rius. . . .

. . . The first Zika-related death was reported in late April and involved a 70-year-old man from the San Juan metro area. He suffered internal bleeding after developing a condition in which antibodies that formed in response to a Zika infection began attacking blood platelet cells. At the time, Rius said there were three other cases of the condition known as severe thrombocytopenia and that those patients recovered.

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(See additional supporting documentation within the links below)

CLICK HERE - Zika virus: first American dies of complications linked to disease

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