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County Health Director: Count on More Zika-Related Birth Defects

submitted by Albert Gomez

The Zika-carrying Aedes aegypti mosquito is photographed through a microscope. (AP Photo/Felipe Dana, File)

CLICK HERE - REPORT - CDC - Vital Signs: Update on Zika Virus–Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure — U.S. Zika Pregnancy Registry, 2016

mypalmbeachpost.com - by John Pacenti - April 8, 2017

Sick of hearing about Zika already? Get used to it as more birth defects related to the virus are expected in 2017 in Florida and throughout the U.S.

This summer, there will be a full-court press by health officials against Zika.

“It’s not something to be taken lightly,” said Dr. Alina Alonso, head of the Palm Beach County Health Department, in an interview with The Palm Beach Post.

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Zika Could End Up Costing Latin America and the Caribbean Up To $18 Billion, UN Reports Finds

                           

CLICK HERE - REPORT - A Socio-economic Impact Assessment of the Zika Virus in Latin America and the Caribbean: with a focus on Brazil, Colombia and Suriname

un.org

6 April 2017 – In addition to the impact on public health, the tangible impact of the Zika outbreak, such as on gross domestic product (GDP), could cost the Latin American and the Caribbean region as much as $18 billion between 2015 and 2017, a new United Nations report has revealed.

The report Socio-economic impact assessment of Zika virus in Latin America and the Caribbean, prepared by the UN Development Programme (UNDP) in partnership with the International Federation of Red Cross and Red Crescent Societies (IFRC), has a particular focus on Brazil, Colombia and Suriname – countries that first reported the outbreak in October-November 2015.

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Dengue May Bring Out the Worst in Zika

           

Brazilian soldiers last year led a battle against Zika in a door-to-door campaign about how to control mosquitoes that carry the disease.  EVARISTO SA/AFP/GETTY IMAGES

CLICK HERE - Science - Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

sciencemag.org - by Jon Cohen - March 30, 2017

Close relatives have complicated relationships with each other even in the viral world. A new mouse study shows that if the animals have antibodies from dengue or West Nile virus, it sets them up for more severe disease from their close cousin, Zika virus.

If such "antibody-dependent enhancement" (ADE) also takes place in people, it could have helped fuel Zika's recent explosion in Brazil, where more than 90% of people in some communities have been infected with dengue. ADE could also complicate the development of vaccines for West Nile, dengue, and Zika. And with the onset of spring reigniting local transmission of Zika last week in the continental United States—where West Nile is widespread—ADE could give epidemiologists a new window into transmission and disease patterns.

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Why Didn't Zika Cause A Surge In Microcephaly In 2016?

           

A family member holds twins Eloisa (left) and Eloa, both 8 months old and born with microcephaly, during a Christmas gathering. The mother of the twins, Raquel, who lives in Brazil, said she contracted Zika during her pregnancy.  Mario Tama/Getty Images

CLICK HERE - NEJM - Zika Virus Infection and Associated Neurologic Disorders in Brazil

CLICK HERE - Science - Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

npr.org - by Michaeleen Doucleff - March 30, 2017

Back in 2015, Brazil reported a horrific a surge in birth defects. Thousands of babies were born with brain damage and abnormally small heads, a condition called microcephaly.

Scientists quickly concluded the Zika virus was the culprit. So when Zika returned last year during Brazil's summer months of December, January and February — when mosquitoes are most active — health officials expected another surge in microcephaly cases.

But that never happened.

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Testing for Zika Virus: There's an App for That

           

Sandia National Laboratories chemical engineer and lead paper author Aashish Priye offers a view into the Zika box prototype, along with co-authors Sara Bird, a virologist, center, and a biomedical engineer.  Credit: Randy Wong

CLICK HERE - Scientific Reports - A smartphone-based diagnostic platform for rapid detection of Zika, chikungunya, and dengue viruses

sciencedaily.com - DOE/Sandia National Laboratories - March 20, 2017 - 

Prototype dramatically cuts cost, time for detection of mosquito-borne illness

Add rapid, mobile testing for Zika and other viruses to the list of things that smartphone technology is making possible. Researchers have developed a smartphone-controlled, battery-operated diagnostic device that weighs under a pound, costs as little as $100 and can detect Zika, dengue and chikungunya within 30 minutes.

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African Strain of Zika Kills Placenta Cells in Days

futurity.org - University of Missouri - posted by Jeff Sossamon - March 9, 2017

CLICK HERE - STUDY - PNAS - Vulnerability of primitive human placental trophoblast to Zika virus

Infection of pregnant women by the Asian strain of Zika virus has been linked to brain abnormalities such as microcephaly in their infants. It’s not clear, however, at what stage of pregnancy the human fetus is most susceptible to the disease.

A new study shows the human fetus may be most vulnerable to Zika infection very early in pregnancy. In addition, the lesser-known African strain of Zika might possibly cause nearly immediate death of the placenta.

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Sperm Donated in Florida May Contain Zika, CDC Says

CLICK HERE - CDC identifies potential risk of Zika virus transmission since June 15, 2016, in Miami-Dade, Broward, and Palm Beach counties

cnn.com - by Debra Goldschmidt - March 13, 2017

Sperm donated in three Florida counties since June 15 may be infected with the Zika virus, the United States Centers for Disease Control and Prevention cautioned Monday.

"When semen is donated it can be stored frozen for periods of time. It does not necessarily inactivate Zika, so it could be stored in tissue banks, used subsequently and people should be made aware," said Dr. Peter Marks, director of the Center for Biologics Evaluation and Research at the US Food and Drug Administration. He went on to say having this information can help individuals make informed decisions and they "might want to use these donations from other sources."

Sources other than the 12 sperm banks in Miami-Dade, Palm Beach and Broward counties of Florida, that is.

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Researchers Sound Alarm Over Zika's Potentially Harmful Heart Effects

Small case report suggests Zika-linked birth defects may only be 'tip of the iceberg'

CLICK HERE - RESEARCH - Myocarditis, Heart Failure and Arrhythmias in Patients With Zika

eurekalert.org - American College of Cardiology - March 9, 2017

As the Zika virus continues to spread globally, new evidence has emerged about the virus's potentially detrimental effects on the heart, according to data scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session.

The study--the first to report Zika-related heart troubles following infection--included adult patients with no prior history of cardiovascular disease who were treated at the Institute of Tropical Medicine in Caracas, Venezuela, one of the epicenters of the Zika virus outbreak. All but one patient developed a dangerous heart rhythm problem and two-thirds had evidence of heart failure, a condition in which the heart can't pump enough blood to meet the body's needs.

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Will a New Glass Battery Accelerate the End of Oil?

John Goodenough, coinventor of the lithium-ion battery, heads a team of researchers developing the technology that could one day supplant it.  Photo: Cockrell School of Engineering

spectrum.ieee.org - by Mark Anderson - March 3, 2017

Electric car purchases have been on the rise lately, posting an estimated 60 percent growth rate last year. They’re poised for rapid adoption by 2022, when EVs are projected to cost the same as internal combustion cars. However, these estimates all presume the incumbent lithium-ion battery remains the go-to EV power source. So, when researchers this week at the University of Texas at Austin unveiled a new, promising lithium- or sodium-glass battery technology, it threatened to accelerate even rosy projections for battery-powered cars.

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Genomics Reveal Surprises About Florida Zika Outbreak

medscape.com - Damian McNamara - March 4, 2017

CLICK HERE - bioRXiv - Multiple introductions of Zika virus into the United States revealed through genomic epidemiology

CLICK HERE - PUBLICATIONS - Kristian G Andersen - The Scripps Research Institute - Genomics, Evolution, Immunology, Infectious diseases

LA JOLLA, California — The Zika virus outbreak in the United States in 2016 was caused by multiple infected travelers arriving in South Florida, not by a single "patient zero," genomic research has revealed.

Reporting here at the 10th Future of Genomic Medicine Conference, Kristian Andersen, PhD, from Scripps Translational Science Institute in La Jolla, California, and his team identified four different "introductions" of the Zika virus during the outbreak using genomic sequencing by testing samples from 17 people.

Extrapolating this to the total number of infected people, "the number of introductions that caused the outbreak in Miami is quite substantial," maybe on the order of 30, he explained.

Genomic sequencing of the virus from mosquitos and patients also revealed that Caribbean travelers were the primary means of introduction.

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